Fri Jun 03 2022

61 articles - From Friday May 27 2022 to Friday Jun 03 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Ann Intern Med

Accuracy and Efficiency of Machine Learning-Assisted Risk-of-Bias Assessments in "Real-World" Systematic Reviews : A Noninferiority Randomized Controlled Trial.

In health-related systematic reviews, RoB assessments conducted with RobotReviewer assistance are noninferior in accuracy to those conducted without RobotReviewer assistance. Primary funding source University College London and Monash University.

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Friend or Foe? The Role of Robots in Systematic Reviews.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality : A Large Prospective Cohort Study.

Moderate consumption of unsweetened and sugar-sweetened coffee was associated with lower risk for death. Primary funding source National Natural Science Foundation of China, Young Elite Scientist Sponsorship Program by CAST, and Project Supported by Guangdong Basic and Applied Basic Research Foundation.

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Lancet

Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.

The largest shortages are in low-income settings, highlighting the need for increased financing and coordination to train, employ, and retain human resources in the health sector. Actual HRH shortages might be larger than estimated because minimum thresholds for each cadre of health workers are benchmarked on health systems that most efficiently translate human resources into UHC attainment. Funding Bill & Melinda Gates Foundation.

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Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials.

The death in the risankizumab-treated patient was deemed unrelated to the study drug. Interpretation Risankizumab was effective and well tolerated as induction therapy in patients with moderately to severely active Crohn's disease. Funding AbbVie.

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Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial.

Adverse event rates were similar among groups, and the most frequently reported adverse events in al treatment groups were worsening Crohn's disease, arthralgia, and headache. Interpretation Subcutaneous risankizumab is a safe and efficacious treatment for maintenance of remission in patients with moderately to severely active Crohn's disease and offers a new therapeutic option for a broad range of patients by meeting endpoints that might change the future course of disease. Funding AbbVie.

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Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials.

There were no treatment-related deaths. Interpretation Upadacitinib demonstrated a positive efficacy and safety profile and could be an effective treatment option for patients with moderately to severely active ulcerative colitis. Funding AbbVie.

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N Engl J Med

Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer.

The engineered T cells constituted more than 2% of al the circulating peripheral-blood T cells 6 months after the cell transfer. In this patient, TCR gene therapy targeting the KRAS G12D driver mutation mediated the objective regression of metastatic pancreatic cancer. (Funded by the Providence Portland Medical Foundation.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Rethinking Professionalism Assessments in Medical Education.

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Lancet

A hunger for action.

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Offline: The fairy tale of Paris.

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N Engl J Med

Another Rescue Therapy Option for Patients with Moderate-to-Severe Asthma.

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Audio Interview: Dissecting the Host Response to SARS-CoV-2.

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T-Cell Immunotherapy against Mutant KRAS for Pancreatic Cancer.

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Targeting Cytotoxic T Cells to Tumor.

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The Science behind the Study.

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Uses of GFR and Albuminuria Level in Acute and Chronic Kidney Disease.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Adverse pregnancy outcomes: biological essentialism versus embodied biology - Authors' reply.

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Adverse pregnancy outcomes: biological essentialism versus embodied biology.

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The Biden administration's unfulfilled promise of humane border policies.

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Violence against health-care workers in the Philippines.

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N Engl J Med

Cemented or Uncemented Hemiarthroplasty for Hip Fracture.

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Cemented or Uncemented Hemiarthroplasty for Hip Fracture.

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Cemented or Uncemented Hemiarthroplasty for Hip Fracture. Reply.

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Daily Urinary Sodium and Potassium Excretion and Cardiovascular Risk.

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Daily Urinary Sodium and Potassium Excretion and Cardiovascular Risk.

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Daily Urinary Sodium and Potassium Excretion and Cardiovascular Risk.

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Daily Urinary Sodium and Potassium Excretion and Cardiovascular Risk. Reply.

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Racial and Ethnic Diversity of U.S. Residency Programs, 2011-2019.

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Reassessing Human Adipose Tissue.

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Reassessing Human Adipose Tissue.

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Reassessing Human Adipose Tissue.

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Reassessing Human Adipose Tissue. Reply.

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Thyroidectomy without Radioiodine in Low-Risk Thyroid Cancer.

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Thyroidectomy without Radioiodine in Low-Risk Thyroid Cancer.

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Thyroidectomy without Radioiodine in Low-Risk Thyroid Cancer.

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Thyroidectomy without Radioiodine in Low-Risk Thyroid Cancer. Reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals On Call - Monkeypox: Should We Worry About Another Pandemic?

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Care of Patients With New, Continuing, or Recurring Symptoms After Acute SARS-CoV-2 Infection.

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Summary for Patients: Association of Sweetened and Unsweetened Coffee Intake With Risk for Death.

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The Potential Health Benefit of Coffee: Does a Spoonful of Sugar Make It All Go Away?

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Lancet

A cerebellar hemangioblastoma and visual and sensory disturbances presenting post partum.

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Calls for independent evaluation of ACT-A welcomed.

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COVID-19 boosters and building trust among UK minority ethnic communities.

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Helen Hansen: developing structural humility in medicine.

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Infectious diseases science in Africa takes a leading place in the world.

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Is the US infant formula shortage an avoidable crisis?

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Pandemic preparedness means policy makers need to work with social scientists.

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Pushing for polio eradication.

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Risankizumab for Crohn's disease.

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Sandstorms hit Iraq, sending thousands to hospital.

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Upadacitinib for ulcerative colitis.

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Urgent need to invest in health and care workers.

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Why stories about illness matter.

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N Engl J Med

Daughters' Keeper - The Care and Treatment of Black Girls in America.

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Eruptive Xanthomas with Branching Projections.

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Eruptive Xanthomas.

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Perverse Incentives - HIV Prevention and the 340B Drug Pricing Program.

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Routine Removal of Inferior Vena Cava Filters.

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The After-Dinner Dip.

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Turbocharging the T Cell to Fight Cancer.

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